[Comparative evaluation of the neuroprotective activity of phenotropil and piracetam in laboratory animals with experimental cerebral ischemia]

Eksp Klin Farmakol. Mar-Apr 2007;70(2):24-9.
[Article in Russian]

Abstract

The neuroprotective properties of phenotropil and piracetam were studied in Wistar rats with low and high sensitivity with respect to cerebral ischemia caused by bilateral irreversible simultaneous occlusion of carotid arteries and gravitational overload in craniocaudal vector. In addition, the effects of both drugs on microcirculation in the brain cortex under ischemic injury conditions were studied. Phenotropil and (to a lower extent) piracetam reduced the extent of neuralgic deficiency manifestations, retained the locomotor, research, and memory functions in animals with gravitational cerebral ischemia, increased the survival of experimental animals, and favored the restoration of local cerebral flow upon the occlusion of carotid arteries.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Brain Ischemia / drug therapy*
  • Brain Ischemia / etiology
  • Brain Ischemia / physiopathology
  • Carotid Artery, Common
  • Carotid Stenosis / complications
  • Cerebrovascular Circulation / drug effects*
  • Gravity, Altered / adverse effects
  • Male
  • Microcirculation / drug effects
  • Neuroprotective Agents / administration & dosage
  • Neuroprotective Agents / therapeutic use*
  • Piracetam / administration & dosage
  • Piracetam / therapeutic use*
  • Rats
  • Rats, Wistar

Substances

  • Neuroprotective Agents
  • Piracetam