[Use of antagonistic Bacillus subtilis bacteria for treatment of nosocomial urinary tract infections]

Zh Mikrobiol Epidemiol Immunobiol. Mar-Apr 2007;(2):90-3.
[Article in Russian]


Effect of Bactisporin--a probiotic, containing spores of aerobic Bacillus subtilis 3H bacterium--for complex treatment of patients with nosocomial urinary tract infections was studied. 68 Cultures of different species of conditionally pathogenic bacteria were isolated from urine of the patients. Susceptibility of the isolated cultures to antibiotics before and after application of B. subtilis 3H metabolites was determined. The metabolites were accumulated on potato-glucose agar (PGA) while bacterium was cultivated on kapron membranes placed on surface of the medium. Influence of obtained metabolites on isolated strains was assessed by cultivation of each strain in metabolites-rich PGA during 24 h. Metabolites of B. subtilis led to decrease in resistance of isolated uropathogenic microflora to antibiotics. Use of Bactisporin in complex treatment of nosocomial urinary tract infections resulted in accelerated elimination of causative microorganism.

Publication types

  • Clinical Trial
  • English Abstract

MeSH terms

  • Administration, Intravesical
  • Administration, Oral
  • Antibiosis
  • Bacillus subtilis* / physiology
  • Bacteria / drug effects
  • Bacteria / isolation & purification
  • Cross Infection / microbiology
  • Cross Infection / therapy*
  • Culture Media, Conditioned / pharmacology
  • Humans
  • Microbial Sensitivity Tests
  • Probiotics / administration & dosage
  • Probiotics / pharmacology
  • Probiotics / therapeutic use*
  • Treatment Outcome
  • Urinary Tract Infections / microbiology
  • Urinary Tract Infections / therapy*


  • Culture Media, Conditioned