Clinical Characteristics and Outcome of Candida Keratitis

Am J Ophthalmol. 2007 Jun;143(6):1043-1045. doi: 10.1016/j.ajo.2007.02.016.

Abstract

Purpose: To characterize the clinical features and therapeutic outcome of Candida keratitis.

Design: Retrospective, observational case series.

Methods: We reviewed 26 patients treated for Candida keratitis, including two with recurrent keratitis and one with bilateral infection.

Results: Of 29 keratitis episodes resulting from Candida albicans (n = 20) or Candida parapsilosis (n = 9), 16 (55%) complicated chronic ocular surface disease, and nine (31%) followed previous keratoplasty. Only two were clinically suspected to have keratomycosis at initial presentation, and 21 (72%) used antibacterial therapy before corneal scrapings. Reconstructive keratoplasty occurred more often in previously grafted eyes (P = .03). Visual outcome was 20/60 or better in six (100%) medically treated eyes with good presenting visual acuity but in only five eyes (24%) with worse initial vision (P = .002).

Conclusions: Candida keratitis is an opportunistic infection of a compromised cornea that often is misdiagnosed initially and, despite antifungal therapy, occasionally requires corneal grafting.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Amphotericin B / administration & dosage
  • Antifungal Agents / administration & dosage
  • Candidiasis / diagnosis*
  • Candidiasis / drug therapy
  • Corneal Transplantation
  • Corneal Ulcer / diagnosis*
  • Corneal Ulcer / drug therapy
  • Eye Infections, Fungal / diagnosis*
  • Eye Infections, Fungal / drug therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Recurrence
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome
  • Visual Acuity

Substances

  • Antifungal Agents
  • Amphotericin B