Comparison of central corneal thickness measurements by visante anterior segment optical coherence tomography with ultrasound pachymetry

Am J Ophthalmol. 2007 Jun;143(6):1047-9. doi: 10.1016/j.ajo.2007.01.050.


Purpose: To compare the measurement of the central corneal thickness (CCT) by Visante (Carl Zeiss Meditec, Dublin, California, USA) anterior segment optical coherence tomography (AS-OCT) with ultrasound pachymetry.

Design: Population-based, cross-sectional study.

Methods: Participants were part of a population-based study of 3280 Malay subjects aged 40 to 80 years in Singapore. Ultrasound pachmetry of CCT was performed on all participants and approximately 10% underwent further evaluation with AS-OCT.

Results: Two hundred and eighty-five consecutive subjects were included, with a mean age of 57.9 (+/- 10.8) years. CCT as measured by ultrasound pachymetry was highly correlated with the equivalent AS-OCT reading (The Pearson correlation coefficient = 0.93, P < .001). However, Bland-Altman analysis showed that CCT as measured by ultrasound pachymetry was significantly higher by 16.5 +/- 11.7 microm (limits of agreement -6.1 to 39.1, P < .001).

Conclusions: CCT measured by Visante AS-OCT was highly correlated with that from ultrasound pachymetry. However, CCT readings by Visante AS-OCT were consistently less than that of ultrasound pachymetry.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Body Weights and Measures
  • Cornea / anatomy & histology*
  • Cornea / diagnostic imaging*
  • Cross-Sectional Studies
  • Diagnostic Techniques, Ophthalmological / instrumentation*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tomography, Optical Coherence / methods*
  • Ultrasonography / methods*