Apolipoprotein E polymorphisms in patients with primary open-angle glaucoma

Am J Ophthalmol. 2007 Jun;143(6):1059-60. doi: 10.1016/j.ajo.2007.01.031.


Purpose: To investigate apolipoprotein E (APOE) polymorphisms, which are known to influence the risk of Alzheimer disease (AD), in patients with primary open-angle glaucoma (POAG).

Design: Retrospective case-control association study.

Methods: Patients with POAG (n = 242) and controls (n = 187) were analyzed for the APOE epsilon 2/epsilon 3/epsilon 4 polymorphisms using minisequencing technique.

Results: The Alzheimer-associated APOE epsilon 4 allele had similar frequencies in the POAG group and in the control group. There was no difference between cases and controls with regard to APOE genotypes.

Conclusions: If a common pathogenic mechanism exists for the two age-related neurodegenerative diseases, POAG and AD, it does not involve APOE polymorphisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Alzheimer Disease / genetics
  • Apolipoprotein E2 / genetics*
  • Apolipoprotein E3 / genetics*
  • Apolipoprotein E4 / genetics*
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genotype
  • Glaucoma, Open-Angle / genetics*
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Retrospective Studies


  • Apolipoprotein E2
  • Apolipoprotein E3
  • Apolipoprotein E4