Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR

Nucl Recept Signal. 2007 May 17;5:e004. doi: 10.1621/nrs.05004.

Abstract

Proline-, glutamic acid-, and leucine-rich protein (PELP)1, also known as modulator of nongenomic actions of the estrogen receptor (MNAR), is a novel nuclear receptor coregulator with a multitude of functions. PELP1/MNAR serves as a scaffolding protein that couples various signaling complexes with nuclear receptors and participates in genomic and nongenomic functions. Recent data suggest that PELP1/MNAR expression is deregulated in several cancers, including breast, endometrial, prostate, and ovarian cancer, and that PELP1/MNAR interacts with several oncogenes. In this review, we summarize the emerging biological properties and functions of PELP1/MNAR.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / metabolism*
  • Co-Repressor Proteins
  • Humans
  • Models, Biological*
  • Signal Transduction / physiology*
  • Trans-Activators / genetics
  • Trans-Activators / metabolism
  • Trans-Activators / physiology*
  • Transcription Factors

Substances

  • Co-Repressor Proteins
  • PELP1 protein, human
  • Trans-Activators
  • Transcription Factors