Retinaldehyde represses adipogenesis and diet-induced obesity

Nat Med. 2007 Jun;13(6):695-702. doi: 10.1038/nm1587. Epub 2007 May 27.


The metabolism of vitamin A and the diverse effects of its metabolites are tightly controlled by distinct retinoid-generating enzymes, retinoid-binding proteins and retinoid-activated nuclear receptors. Retinoic acid regulates differentiation and metabolism by activating the retinoic acid receptor and retinoid X receptor (RXR), indirectly influencing RXR heterodimeric partners. Retinoic acid is formed solely from retinaldehyde (Rald), which in turn is derived from vitamin A. Rald currently has no defined biologic role outside the eye. Here we show that Rald is present in rodent fat, binds retinol-binding proteins (CRBP1, RBP4), inhibits adipogenesis and suppresses peroxisome proliferator-activated receptor-gamma and RXR responses. In vivo, mice lacking the Rald-catabolizing enzyme retinaldehyde dehydrogenase 1 (Raldh1) resisted diet-induced obesity and insulin resistance and showed increased energy dissipation. In ob/ob mice, administrating Rald or a Raldh inhibitor reduced fat and increased insulin sensitivity. These results identify Rald as a distinct transcriptional regulator of the metabolic responses to a high-fat diet.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3-L1 Cells
  • Adipogenesis / genetics
  • Adipogenesis / physiology*
  • Animals
  • Diet / adverse effects*
  • Female
  • Growth Inhibitors / deficiency
  • Growth Inhibitors / genetics
  • Growth Inhibitors / physiology*
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Obese
  • NIH 3T3 Cells
  • Obesity / metabolism*
  • Obesity / physiopathology
  • Obesity / prevention & control*
  • Rabbits
  • Retinaldehyde / biosynthesis
  • Retinaldehyde / genetics
  • Retinaldehyde / physiology*


  • Growth Inhibitors
  • Retinaldehyde