Effects of six weeks of beta-hydroxy-beta-methylbutyrate (HMB) and HMB/creatine supplementation on strength, power, and anthropometry of highly trained athletes

J Strength Cond Res. 2007 May;21(2):419-23. doi: 10.1519/R-15974.1.


This study investigated the effects of 6 weeks of dietary supplementation of beta-hydroxy-beta-methylbutyrate (HMB) and HMB combined with creatine monohydrate (HMBCr) on the muscular strength and endurance, leg power, and anthropometry of elite male rugby league players. The subjects were divided into a control group (n = 8), a HMB group (n = 11; 3 g.d(-1)) or a HMBCr group (n = 11; 12 g.d(-1) with 3 g HMB, 3 g Cr, 6 g carbohydrates). Three repetition maximum lifts on bench press, deadlifts, prone row, and shoulder press, maximum chin-up repetitions, 10-second maximal cycle test, body mass, girths, and sum of skinfolds were assessed pre- and postsupplementation. Statistical analysis revealed no effect of HMB or HMBCr on any parameter compared with presupplementation measures or the control group. HMB and HMBCr were concluded to have no ergogenic effect on muscular strength and endurance, leg power, or anthropometry when taken orally by highly trained male athletes over 6 weeks.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Analysis of Variance
  • Anthropometry
  • Creatine / administration & dosage*
  • Dietary Supplements*
  • Football / physiology*
  • Humans
  • Male
  • Muscle Strength / drug effects*
  • Muscle, Skeletal / drug effects*
  • Oxygen Consumption / drug effects
  • Oxygen Consumption / physiology
  • Physical Endurance / drug effects
  • Task Performance and Analysis
  • Valerates / administration & dosage*


  • Valerates
  • beta-hydroxyisovaleric acid
  • Creatine