Levonorgestrel intrauterine system: bleeding disorders and anticoagulant therapy

Contraception. 2007 Jun;75(6 Suppl):S123-9. doi: 10.1016/j.contraception.2007.01.005. Epub 2007 Mar 23.


Hemostatic disorders in women are frequently associated with long-standing menorrhagia. This leads to significant morbidity and adversely affects quality of life. Management of these women poses a particular challenge; medical treatments may be contraindicated, and surgery carries additional risks. The levonorgestrel intrauterine system (LNG-IUS) has been shown to be highly efficacy in reducing menstrual blood loss in women with normal coagulation. It is also a reliable and reversible contraceptive. Data on the use of this system in women with bleeding disorders or those receiving anticoagulant therapy are limited. Analysis of data from four reported studies suggests that LNG-IUS is a viable and safe option for the management of menorrhagia in these women. Whether the underlying hemostatic disorders lead to a shorter duration of action or prolonged irregular bleeding/spotting post insertion is unknown and requires large prospective studies. Proper counselling remains crucial for patients' satisfaction.

Publication types

  • Review

MeSH terms

  • Anticoagulants / therapeutic use
  • Blood Coagulation Disorders, Inherited* / complications
  • Blood Coagulation Disorders, Inherited* / drug therapy
  • Contraceptive Agents, Female / administration & dosage*
  • Dysmenorrhea / complications
  • Dysmenorrhea / drug therapy
  • Female
  • Humans
  • Intrauterine Devices, Medicated*
  • Levonorgestrel / administration & dosage*
  • Menorrhagia / drug therapy*
  • Menorrhagia / etiology


  • Anticoagulants
  • Contraceptive Agents, Female
  • Levonorgestrel