Dorsal root ganglion regulates the transient ERK activation in the dorsal horn of the spinal cord during development

Taro Kato; Ritsuko Ohtani-Kaneko; Takashi Shiga

doi:10.1016/j.neures.2007.04.010

Dorsal root ganglion regulates the transient ERK activation in the dorsal horn of the spinal cord during development

Neurosci Res. 2007 Aug;58(4):402-5. doi: 10.1016/j.neures.2007.04.010. Epub 2007 Apr 29.

Authors

Taro Kato¹, Ritsuko Ohtani-Kaneko, Takashi Shiga

Affiliation

¹ Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.

PMID: 17532077
DOI: 10.1016/j.neures.2007.04.010

Abstract

In the dorsal horn of the chick embryo spinal cord, extracellular signal-regulated kinase (ERK) was phosphorylated transiently during embryonic days 6 and 9. Co-culture studies suggested that dorsal root ganglion (DRG) activated ERK in the dorsal horn. Brain-derived neurotrophic factor (BDNF) activated ERK in the dorsal horn, and anti-BDNF blocked the DRG-induced ERK activation. These results suggest roles of BDNF in the DRG-induced ERK activation in the embryonic dorsal horn.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies / pharmacology
Brain-Derived Neurotrophic Factor / immunology
Brain-Derived Neurotrophic Factor / pharmacology
Chick Embryo
Enzyme Activation / drug effects
Enzyme Activation / physiology
Extracellular Signal-Regulated MAP Kinases / metabolism*
Ganglia, Spinal / physiology*
In Vitro Techniques
Spinal Cord* / anatomy & histology
Spinal Cord* / embryology
Spinal Cord* / enzymology
Time Factors

Substances

Antibodies
Brain-Derived Neurotrophic Factor
Extracellular Signal-Regulated MAP Kinases