Morphometry of the corpus callosum in normal aging and Alzheimer's disease

J Neural Transm Suppl. 1991;33:35-8. doi: 10.1007/978-3-7091-9135-4_6.

Abstract

Changes of the human corpus callosum in normal aging and Alzheimer's disease were analysed by means of morphometry. A standardized computerized evaluation program was implemented allowing objective, quantitative and reproducible data. The various parts of the corpus callosum showed a different pattern of changes in normal aging as compared to Alzheimer's disease. In conclusion, in normal aging affects mostly the front-temporal interhemispheric fiber systems, whereas in Alzheimer's disease the parietotemporal commissural fibers are altered.

MeSH terms

  • Aging / pathology*
  • Alzheimer Disease / pathology*
  • Corpus Callosum / anatomy & histology
  • Corpus Callosum / pathology*
  • Humans
  • Reference Values