Orphan nuclear receptors in drug discovery

Drug Discov Today. 2007 Jun;12(11-12):440-5. doi: 10.1016/j.drudis.2007.04.006. Epub 2007 Apr 26.

Abstract

Orphan nuclear receptors provide a unique resource for uncovering novel regulatory systems that impact human health and also provide drug targets for a variety of human diseases. Ligands of nuclear receptors have been used in several important therapeutic areas, such as breast cancers, skin disorders and diabetes. Orphan nuclear receptors, therefore, represent a tremendous opportunity in understanding and treating human diseases. Here, I highlight recent advances in the use of orphan nuclear receptors and their potential as targets for drug discovery in diabetes, obesity, neurodegenerative diseases and other related disorders.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / drug effects
  • DNA-Binding Proteins / genetics
  • Drug Design
  • Humans
  • Ligands
  • Nuclear Receptor Subfamily 1, Group F, Member 1
  • Nuclear Receptor Subfamily 4, Group A, Member 2
  • Peroxisome Proliferator-Activated Receptors / drug effects
  • Peroxisome Proliferator-Activated Receptors / genetics
  • Pharmacology / trends*
  • Receptors, Cytoplasmic and Nuclear / drug effects*
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Trans-Activators / drug effects
  • Trans-Activators / genetics
  • Transcription Factors / drug effects
  • Transcription Factors / genetics

Substances

  • DNA-Binding Proteins
  • Ligands
  • NR2E1 protein, human
  • NR4A2 protein, human
  • Nuclear Receptor Subfamily 1, Group F, Member 1
  • Nuclear Receptor Subfamily 4, Group A, Member 2
  • Peroxisome Proliferator-Activated Receptors
  • Receptors, Cytoplasmic and Nuclear
  • Trans-Activators
  • Transcription Factors