Circadian clock and breast cancer: a molecular link

Cell Cycle. 2007 Jun 1;6(11):1329-31. doi: 10.4161/cc.6.11.4295. Epub 2007 Jun 12.

Abstract

The circadian clock controls a large array of behavioral and physiological systems of fundamental importance to most organisms. Consequently, abnormal functioning of the clock results in severe dysfunctions and pathologies. Although epidemiological studies show a clear correlation between disruption of circadian rhythms and incidence of breast cancer, a molecular interpretation of how clock-related mechanisms may link to tumor development remains elusive. Here we speculate on the molecular pathways that may couple the circadian machinery to breast cancer.

Publication types

  • Review

MeSH terms

  • ARNTL Transcription Factors
  • Acetylation
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / physiology
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / etiology*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / physiopathology
  • CLOCK Proteins
  • Cell Transformation, Neoplastic / genetics*
  • Chromatin / metabolism
  • Circadian Rhythm / genetics
  • Circadian Rhythm / physiology*
  • Cyclin D1 / physiology
  • Developed Countries
  • Disease Susceptibility
  • Estrogen Receptor alpha / physiology
  • Estrogens
  • Female
  • Gene Expression Regulation
  • Genes, Tumor Suppressor
  • Histone Acetyltransferases / physiology*
  • Histones / metabolism
  • Humans
  • Mammals / physiology
  • Mammary Neoplasms, Experimental / etiology
  • Mammary Neoplasms, Experimental / genetics
  • Mammary Neoplasms, Experimental / physiopathology
  • Melatonin / physiology
  • Mice
  • Models, Biological
  • Neoplasms, Hormone-Dependent / etiology
  • Neoplasms, Hormone-Dependent / genetics
  • Neoplasms, Hormone-Dependent / physiopathology
  • Nuclear Proteins / physiology
  • Protein Processing, Post-Translational / physiology
  • Risk
  • Trans-Activators / physiology*
  • Transcription Factors / physiology

Substances

  • ARNTL Transcription Factors
  • ARNTL protein, human
  • Arntl protein, mouse
  • Basic Helix-Loop-Helix Transcription Factors
  • Chromatin
  • Estrogen Receptor alpha
  • Estrogens
  • Histones
  • Nuclear Proteins
  • Trans-Activators
  • Transcription Factors
  • Cyclin D1
  • CLOCK Proteins
  • CLOCK protein, human
  • Clock protein, mouse
  • Histone Acetyltransferases
  • Melatonin