A facile and modular synthesis of phosphinooxazoline ligands

Kousuke Tani; Douglas C Behenna; Ryan M McFadden; Brian M Stoltz

doi:10.1021/ol070884s

A facile and modular synthesis of phosphinooxazoline ligands

Org Lett. 2007 Jun 21;9(13):2529-31. doi: 10.1021/ol070884s. Epub 2007 May 31.

Authors

Kousuke Tani¹, Douglas C Behenna, Ryan M McFadden, Brian M Stoltz

Affiliation

¹ The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

PMID: 17536810
DOI: 10.1021/ol070884s

Abstract

The copper(I) iodide catalyzed phosphine/aryl halide coupling procedure of Buchwald et al. provides modular, robust, and scaleable access to phosphinooxazoline (PHOX) ligands. The advantages of this method are highlighted by the convenient synthesis of PHOX ligands with varied steric and electronic properties, which would be challenging to synthesize by other protocols.

Publication types

Research Support, Non-U.S. Gov't