Systemic and central amygdala injections of the mGluR2/3 agonist LY379268 attenuate the expression of incubation of sucrose craving in rats

Behav Brain Res. 2007 Aug 6;181(2):292-6. doi: 10.1016/j.bbr.2007.04.019. Epub 2007 May 1.

Abstract

We previously reported that systemic or central amygdala injections of the mGluR(2/3) agonist LY379268 (which decreases glutamate release) prevented enhanced cue-induced cocaine seeking in extinction tests after prolonged withdrawal (incubation of cocaine craving). Here, we report that systemic and central amygdala injections of LY379268 also prevented the enhanced cue-induced sucrose seeking in extinction tests after prolonged sucrose-free period (incubation of sucrose craving). These findings suggest that central amygdala glutamate plays an important role in the incubation of reward craving after withdrawal from both drug and non-drug rewards.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Amino Acids / administration & dosage*
  • Amygdala / drug effects*
  • Amygdala / metabolism
  • Animals
  • Appetitive Behavior / drug effects*
  • Association Learning / physiology
  • Behavior, Addictive / metabolism
  • Behavior, Animal / drug effects*
  • Bridged Bicyclo Compounds, Heterocyclic / administration & dosage*
  • Drug Administration Routes
  • Male
  • Microinjections
  • Rats
  • Rats, Long-Evans
  • Receptors, Metabotropic Glutamate / agonists*
  • Receptors, Metabotropic Glutamate / metabolism
  • Reward*
  • Self Administration
  • Sucrose / administration & dosage

Substances

  • Amino Acids
  • Bridged Bicyclo Compounds, Heterocyclic
  • LY 379268
  • Receptors, Metabotropic Glutamate
  • Sucrose