The discovery of basic fibroblast growth factor/fibroblast growth factor-2 and its role in haematological malignancies

Cytokine Growth Factor Rev. 2007 Jun-Aug;18(3-4):327-34. doi: 10.1016/j.cytogfr.2007.04.011. Epub 2007 May 29.

Abstract

Basic fibroblast growth factor/fibroblast growth factor-2 is one of the best characterized of the pro-angiogenic cytokines. This review describes its history, as well as its role in tumor angiogenesis associated with haematological malignancies, as traced by the main contributions to the international medical literature.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Fibroblast Growth Factor 2 / metabolism*
  • Fibroblast Growth Factor 2 / physiology*
  • Gene Expression Regulation, Neoplastic*
  • Hematologic Neoplasms / metabolism*
  • Humans
  • Lymphoma / metabolism
  • Models, Biological
  • Neovascularization, Pathologic
  • Receptors, Fibroblast Growth Factor / metabolism

Substances

  • Receptors, Fibroblast Growth Factor
  • Fibroblast Growth Factor 2