Protective effects of TJ-960 herbal mixture on hippocampal neuron damage induced by cobalt focus in the cerebral cortex of rats

J Ethnopharmacol. 1991 Aug;34(1):13-9. doi: 10.1016/0378-8741(91)90184-f.


In the cobalt focus experimental epilepsy model, severe hippocampal neuron damage occurs with marked EEG changes. The effects of TJ-960, a herbal medicine formulation, were studied on neuron damage in the CA1 area of rat hippocampus. Continuous oral administration of TJ-960 from one month prior to the cobalt application showed almost complete protection against hippocampal neuron damage induced by cobalt application to the cerebral cortex. TJ-960 also completely inhibited the EEG changes as well as the brain edema induced by cobalt application.

MeSH terms

  • Animals
  • Anticonvulsants / therapeutic use*
  • Body Water / metabolism
  • Brain Chemistry / drug effects
  • Brain Edema / chemically induced
  • Brain Edema / physiopathology
  • Brain Edema / prevention & control
  • Cerebral Cortex / drug effects*
  • Cerebral Cortex / metabolism
  • Cobalt
  • Drugs, Chinese Herbal / therapeutic use*
  • Electroencephalography
  • Epilepsy / chemically induced
  • Epilepsy / physiopathology
  • Epilepsy / prevention & control*
  • Hippocampus / drug effects*
  • Hippocampus / metabolism
  • Neurons / drug effects*
  • Pyramidal Tracts / drug effects
  • Rats
  • Rats, Inbred Strains


  • Anticonvulsants
  • Drugs, Chinese Herbal
  • shosaikoto-go-keishika-shakuyakuto
  • Cobalt