CD16+ Monocyte Subset Preferentially Harbors HIV-1 and Is Expanded in Pregnant Malawian Women With Plasmodium Falciparum Malaria and HIV-1 Infection

J Infect Dis. 2007 Jul 1;196(1):38-42. doi: 10.1086/518443. Epub 2007 May 16.

Abstract

In a cross-sectional study, monocyte subsets in placental, cord, and maternal peripheral blood from pregnant Malawian women with human immunodeficiency virus (HIV)-1 infection and/or malaria were analyzed. HIV-uninfected Malawian women had higher baseline proportions of CD16(+) monocytes than those reported for healthy adults in developed countries. Malaria was associated with an increase in the proportion of CD16(+) monocytes that was significant in women coinfected with HIV-1. CD16(+) monocytes expressed higher CCR5 levels than did CD14(hi)/CD16(-) monocytes and were significantly more likely to harbor HIV-1. These data suggest a role for CD16(+) monocytes in the pathogenesis of maternal malaria and HIV-1 infections.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Blood / immunology
  • Cross-Sectional Studies
  • DNA, Viral / analysis
  • DNA, Viral / genetics
  • Female
  • HIV Infections / complications
  • HIV Infections / immunology*
  • HIV Infections / virology
  • HIV-1 / isolation & purification*
  • Humans
  • Lipopolysaccharide Receptors / analysis
  • Malaria, Falciparum / complications*
  • Malaria, Falciparum / immunology*
  • Malawi
  • Monocytes / virology*
  • Placenta / immunology
  • Polymerase Chain Reaction
  • Pregnancy
  • Pregnancy Complications, Infectious / immunology
  • Pregnancy Complications, Parasitic
  • Receptors, CCR5 / analysis
  • Receptors, IgG / analysis*
  • Umbilical Cord / immunology

Substances

  • DNA, Viral
  • Lipopolysaccharide Receptors
  • Receptors, CCR5
  • Receptors, IgG