Subcutaneous injection of heparin calcium controls chronic disseminated intravascular coagulation associated with inoperable dissecting aortic aneurysm in an outpatient clinic

Intern Med. 2007;46(11):727-32. doi: 10.2169/internalmedicine.46.6155. Epub 2007 Jun 1.

Abstract

Background: Chronic disseminated intravascular coagulation (DIC) is a rare but critical complication of aortic aneurysm, and can represent a difficult long-term management problem. Although surgical correction is the treatment of choice, alternative therapy is required for inoperable patients.

Results: We report herein a case of acute exacerbation of chronic DIC with inoperable dissecting aortic aneurysm, which was recurrent and resistant to regular treatment. Intermittent subcutaneous self-injection of heparin calcium 15,000 units per day achieved stabilization of coagulation and fibrinolytic parameters and relief of the bleeding tendency.

Conclusion: Subcutaneous heparin injection can be an alternative treatment for long-term management of chronic DIC associated with inoperable aortic dissection, beneficial for providing good symptomatic control on an outpatient basis.

Publication types

  • Case Reports

MeSH terms

  • Ambulatory Care Facilities
  • Anticoagulants / administration & dosage
  • Anticoagulants / therapeutic use*
  • Aortic Aneurysm / complications*
  • Aortic Dissection / complications*
  • Disseminated Intravascular Coagulation / drug therapy*
  • Disseminated Intravascular Coagulation / etiology*
  • Heparin / administration & dosage
  • Heparin / therapeutic use*
  • Humans
  • Injections, Subcutaneous
  • Male
  • Middle Aged

Substances

  • Anticoagulants
  • Heparin