Nausea, vomiting, sleep, and restfulness upon discharge home after outpatient anterior cruciate ligament reconstruction with regional anesthesia and multimodal analgesia/antiemesis

Reg Anesth Pain Med. 2007 May-Jun;32(3):193-202. doi: 10.1016/j.rapm.2006.12.002.

Abstract

Background and objectives: We analyzed discharge outcome data after anterior cruciate ligament reconstruction (ACLR) under spinal anesthesia including a perineural femoral catheter and multimodal analgesia/antiemesis. The outcomes specifically addressed in this report are nausea, vomiting, and retching (NVR) and quality of sleep/difficulty falling asleep/daytime restfulness.

Methods: ACLR patients were randomized to saline or 0.25% levobupivacaine as a bolus and/or 50-hour infusion. Patients completed the Quality of Recovery 40-item (QoR-40) survey on postoperative days 1 to 4. We analyzed predictors of perfect responses (i.e., no NVR and perfect sleep-restfulness) by pooling these specific QoR-40 items. Prospectively collected QoR-40 data were analyzed retrospectively.

Results: Data from 233 participants were analyzed. The addition of the femoral nerve block or perineural catheter did not predict associated improvements in NVR or sleep-restfulness. Previous days' NVR was the most consistent predictor of subsequent NVR, whereas gender and opioid consumption were less consistent predictors. Smoking status was not predictive of NVR. Previous days' sleep-restfulness was a consistent predictor of subsequent sleep-restfulness, whereas the presence of any moderate pain was a less consistent predictor of sleep-restfulness.

Conclusions: NVR and quality of sleep-restfulness after the described regional anesthetic with multimodal analgesia and antiemesis is reported. Smoking status was not a predictor of NVR, and gender and opioid consumption were not consistently predictive of NVR. The addition of a femoral nerve block to the described multimodal technique was not associated with NVR or quality of sleep-restfulness.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Ambulatory Surgical Procedures
  • Analgesia / methods*
  • Analgesics, Opioid / therapeutic use
  • Anesthesia, Spinal*
  • Anesthetics, Local / administration & dosage
  • Anterior Cruciate Ligament / surgery*
  • Antiemetics / therapeutic use*
  • Bupivacaine / administration & dosage
  • Bupivacaine / analogs & derivatives
  • Drug Administration Schedule
  • Female
  • Femoral Nerve
  • Humans
  • Levobupivacaine
  • Logistic Models
  • Male
  • Nerve Block
  • Pain Measurement
  • Pain, Postoperative / prevention & control*
  • Patellar Ligament / transplantation
  • Patient Discharge
  • Postoperative Nausea and Vomiting / prevention & control*
  • Retrospective Studies
  • Sleep / drug effects*
  • Surveys and Questionnaires
  • Time Factors
  • Transplantation, Autologous

Substances

  • Analgesics, Opioid
  • Anesthetics, Local
  • Antiemetics
  • Levobupivacaine
  • Bupivacaine