Effects of aerobic exercise on lipids and lipoproteins in adults with type 2 diabetes: a meta-analysis of randomized-controlled trials

Public Health. 2007 Sep;121(9):643-55. doi: 10.1016/j.puhe.2007.02.014. Epub 2007 Jun 1.

Abstract

Objective: To conduct a meta-analysis of randomized-controlled trials in order to examine the effects of 8 weeks or more of aerobic exercise on lipids and lipoproteins in adults with Type 2 diabetes.

Methods: Studies were included if total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), ratio of TC to HDL-C (TC/HDL-C), triglycerides (TG), or all of the above, were assessed. A secondary outcome was glycosylated haemoglobin (HbA1).

Results: Seven studies representing 220 men and women (112 exercise, 108 control) were available for pooling. Using a random-effects model, a statistically significant reduction of about 5% was found for LDL-C, whereas no statistically significant improvements were found for TC, HDL-C, TC/HDL-C or TG. A trend for a statistically significant reduction in HbA1 was also found.

Conclusions: Although our overall results suggest that aerobic exercise lowers LDL-C in adults with Type 2 diabetes, additional randomized-controlled trials are needed on this topic.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Diabetes Mellitus, Type 2 / therapy*
  • Exercise / physiology*
  • Female
  • Glycated Hemoglobin A / physiology
  • Humans
  • Lipids / blood*
  • Lipoproteins / blood
  • Male
  • Middle Aged
  • Randomized Controlled Trials as Topic
  • Triglycerides / blood

Substances

  • Glycated Hemoglobin A
  • Lipids
  • Lipoproteins
  • Triglycerides