Effect of GB virus C co-infection on response to generic HAART in African patients with HIV-1 clade C infection

AIDS. 2007 Jun 19;21(10):1377-9. doi: 10.1097/QAD.0b013e3281532cb8.

Abstract

In 38 African AIDS patients initiating generic HAART, GB virus C (GBV-C) RNA-positive patients retained GBV-C viraemia during 52 weeks of HAART, had a faster decline in HIV viral load (P = 0.03), fewer opportunistic infections (14.3 versus 50%, P = 0.18), and suffered no serious adverse events (none versus 61%, P = 0.008) compared with patients without GBV-C. GBV-C co-infection may be associated with a beneficial effect on African AIDS patients treated with generic HAART.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS-Related Opportunistic Infections / epidemiology
  • Acquired Immunodeficiency Syndrome / complications
  • Acquired Immunodeficiency Syndrome / epidemiology
  • Adult
  • Africa / epidemiology
  • Antiretroviral Therapy, Highly Active / methods*
  • Female
  • Flaviviridae Infections / complications
  • Flaviviridae Infections / epidemiology*
  • GB virus C*
  • HIV Infections / complications
  • HIV Infections / drug therapy*
  • HIV Infections / epidemiology
  • HIV-1*
  • Hepatitis, Viral, Human / complications
  • Hepatitis, Viral, Human / epidemiology*
  • Herpesviridae Infections / complications
  • Herpesviridae Infections / epidemiology
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • RNA, Viral / analysis
  • Retrospective Studies
  • Sarcoma, Kaposi / complications
  • Sarcoma, Kaposi / epidemiology
  • Viremia / complications
  • Viremia / epidemiology

Substances

  • RNA, Viral