Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

Mov Disord. 2007 Jul 30;22(10):1481-4. doi: 10.1002/mds.21399.

Abstract

Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of beta-glucocerebrosidase and the activities of other lysosomal enzymes, alpha-mannosidase, beta-mannosidase, beta-hexosaminidase, and beta-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of alpha-mannosidase, beta-mannosidase, beta-glucocerebrosidase, and beta-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of beta-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.

MeSH terms

  • Aged
  • Chromatography, Ion Exchange / methods
  • Female
  • Humans
  • Hyaluronoglucosaminidase / cerebrospinal fluid*
  • Male
  • Middle Aged
  • Parkinson Disease / cerebrospinal fluid*
  • Statistics, Nonparametric

Substances

  • Hyaluronoglucosaminidase