The nuclear envelope and transcriptional control

Nat Rev Genet. 2007 Jul;8(7):507-17. doi: 10.1038/nrg2122. Epub 2007 Jun 5.


Cells have evolved sophisticated multi-protein complexes that can regulate gene activity at various steps of the transcription process. Recent advances highlight the role of nuclear positioning in the control of gene expression and have put nuclear envelope components at centre stage. On the inner face of the nuclear envelope, active genes localize to nuclear-pore structures whereas silent chromatin localizes to non-pore sites. Nuclear-pore components seem to not only recruit the RNA-processing and RNA-export machinery, but contribute a level of regulation that might enhance gene expression in a heritable manner.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chromatin / physiology
  • Dosage Compensation, Genetic
  • Drosophila melanogaster / genetics
  • Epigenesis, Genetic
  • Gene Expression Regulation*
  • Heterochromatin
  • Models, Genetic
  • Nuclear Envelope / physiology*
  • Nuclear Pore / physiology*
  • RNA, Messenger / metabolism
  • Saccharomyces cerevisiae / genetics
  • Transcription, Genetic
  • X Chromosome


  • Chromatin
  • Heterochromatin
  • RNA, Messenger