Equipment-independent reference values for dopamine transporter imaging with 123I-FP-CIT

Nuklearmedizin. 2007;46(3):107-11.


Aim: Reliable reference values are helpful to interpret and compare the results of dopamine transporter imaging with SPECT. Since semi-quantitative reference values cannot be easily transferred between imaging equipments, this study aimed to establish equipment independent normal values for the true striatal binding of 123I-FP-CIT.

Patients, methods: Specific striatal FP-CIT binding of 6 healthy volunteers and 26 patients with essential tremor were used to generate a reference range by applying an equipment specific resolution dependent factor to compensate for recovery effects. This factor has been determined previously by a series of standardized phantom measurements of an anthropomorphic basal ganglia phantom. Herewith, the resulting DAT binding values represent the expected true specific binding in the striatum.

Results: On average, true specific striatal binding was 5.83 +/- 0.96 in healthy controls, 5.25 +/- 0.67 in patients with essential tremor and 5.36 +/- 0.75 in the entire study cohort.

Conclusion: These preliminary results may serve as a basis for the generation of a generally accepted equipment independent reference range for dopamine transporter imaging with 123I-FP-CIT. By a simple phantom measurement that can be accomplished within one day factors related to specific imaging equipment and processing can be corrected for, resulting in specific binding values which may enable a more standardized interpretation of dopamine transporter scans.

MeSH terms

  • Aged
  • Corpus Striatum / diagnostic imaging*
  • Corpus Striatum / physiopathology
  • Dopamine Plasma Membrane Transport Proteins / analysis*
  • Essential Tremor / diagnostic imaging*
  • Essential Tremor / physiopathology
  • Female
  • Humans
  • Indicators and Reagents
  • Iodine Radioisotopes*
  • Male
  • Middle Aged
  • Reference Values
  • Tomography, Emission-Computed, Single-Photon*


  • Dopamine Plasma Membrane Transport Proteins
  • Indicators and Reagents
  • Iodine Radioisotopes