Development of diabetes mellitus in two boys after the initiation of growth hormone therapy

J Pediatr Endocrinol Metab. 2007 Apr;20(4):541-4. doi: 10.1515/jpem.2007.20.4.541.

Abstract

In addition to its growth promoting properties, growth hormone (GH) has anti-insulin effects that could cause hyperglycemia. Development of diabetes mellitus as a result of GH therapy has been an ever-present, albeit rarely reported, concern. This report is that of two adolescent boys who developed diabetes mellitus after the initiation of treatment with GH.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Blood Glucose / analysis
  • Body Height / drug effects
  • Body Weight / drug effects
  • Diabetes Mellitus / chemically induced*
  • Glycated Hemoglobin
  • Growth Disorders / drug therapy*
  • Hemoglobins / analysis
  • Human Growth Hormone / adverse effects*
  • Human Growth Hormone / therapeutic use
  • Humans
  • Male

Substances

  • Blood Glucose
  • Glycated Hemoglobin A
  • Hemoglobins
  • hemoglobin A1c protein, human
  • Human Growth Hormone