Near-infrared Resonant Nanoshells for Combined Optical Imaging and Photothermal Cancer Therapy

Nano Lett. 2007 Jul;7(7):1929-34. doi: 10.1021/nl070610y. Epub 2007 Jun 6.

Abstract

Metal nanoshells are core/shell nanoparticles that can be designed to either strongly absorb or scatter within the near-infrared (NIR) wavelength region ( approximately 650-950 nm). Nanoshells were designed that possess both absorption and scattering properties in the NIR to provide optical contrast for improved diagnostic imaging and, at higher light intensity, rapid heating for photothermal therapy. Using these in a mouse model, we have demonstrated dramatic contrast enhancement for optical coherence tomography (OCT) and effective photothermal ablation of tumors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Mice
  • Nanoparticles*
  • Neoplasms, Experimental / diagnosis*
  • Neoplasms, Experimental / therapy*
  • Phototherapy*
  • Spectroscopy, Near-Infrared*
  • Tomography, Optical Coherence*