FGF21: a missing link in the biology of fasting

Cell Metab. 2007 Jun;5(6):405-7. doi: 10.1016/j.cmet.2007.05.010.


A sufficient energy supply is essential for life; consequently, multiple mechanisms have evolved to ensure both energy availability and conservation during fasting and starvation. Two reports in this issue of Cell Metabolism (Badman et al., 2007; Inagaki et al., 2007) demonstrate that FGF21, a circulating protein produced in the liver in response to the PPARalpha transcription factor, is a "missing link" in the biology of fasting, inducing adipose tissue lipolysis, liver ketogenesis, and metabolic adaptation to the fasting state.

Publication types

  • Comment

MeSH terms

  • Fasting / physiology*
  • Fibroblast Growth Factors / physiology*
  • Humans
  • Liver / cytology
  • Liver / metabolism*
  • PPAR alpha / physiology


  • PPAR alpha
  • fibroblast growth factor 21
  • Fibroblast Growth Factors