Fusaristatins A and B, two new cyclic lipopeptides from an endophytic Fusarium sp

J Antibiot (Tokyo). 2007 May;60(5):309-16. doi: 10.1038/ja.2007.39.

Abstract

Two new cyclic lipopeptides, fusaristatins A (1) and B (2) were isolated from rice cultures of a Fusarium sp. YG-45 in the course of a screening of endophytic fungi. Their structures of 1 and 2 were determined by spectroscopic methods. 2 showed a moderate inhibitory effect on topoisomerases I (IC50: 73 microM) and II (IC50: 98 microM) without cleavable complexes. Furthermore, 1 and 2 showed the growth-inhibitory activity toward lung cancer cells LU 65 with IC50 values of 23 and 7 microM, respectively.

MeSH terms

  • Antibiotics, Antineoplastic / pharmacology
  • Bacteria / drug effects
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Culture Media
  • Depsipeptides / isolation & purification*
  • Depsipeptides / pharmacology
  • Drug Screening Assays, Antitumor
  • Enzyme Inhibitors / pharmacology
  • Fermentation
  • Fungi / drug effects
  • Fusarium / chemistry*
  • Humans
  • Maackia / microbiology
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Topoisomerase I Inhibitors
  • Topoisomerase II Inhibitors

Substances

  • Antibiotics, Antineoplastic
  • Culture Media
  • Depsipeptides
  • Enzyme Inhibitors
  • Topoisomerase I Inhibitors
  • Topoisomerase II Inhibitors
  • fusaristatin A
  • fusaristatin B