Abstract
Two new cyclic lipopeptides, fusaristatins A (1) and B (2) were isolated from rice cultures of a Fusarium sp. YG-45 in the course of a screening of endophytic fungi. Their structures of 1 and 2 were determined by spectroscopic methods. 2 showed a moderate inhibitory effect on topoisomerases I (IC50: 73 microM) and II (IC50: 98 microM) without cleavable complexes. Furthermore, 1 and 2 showed the growth-inhibitory activity toward lung cancer cells LU 65 with IC50 values of 23 and 7 microM, respectively.
MeSH terms
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Antibiotics, Antineoplastic / pharmacology
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Bacteria / drug effects
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Culture Media
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Depsipeptides / isolation & purification*
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Depsipeptides / pharmacology
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Drug Screening Assays, Antitumor
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Enzyme Inhibitors / pharmacology
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Fermentation
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Fungi / drug effects
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Fusarium / chemistry*
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Humans
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Maackia / microbiology
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Topoisomerase I Inhibitors
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Topoisomerase II Inhibitors
Substances
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Antibiotics, Antineoplastic
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Culture Media
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Depsipeptides
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Enzyme Inhibitors
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Topoisomerase I Inhibitors
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Topoisomerase II Inhibitors
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fusaristatin A
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fusaristatin B