HPV Type-Specific Risks of High-Grade CIN During 4 Years of Follow-Up: A Population-Based Prospective Study

Br J Cancer. 2007 Jul 2;97(1):129-32. doi: 10.1038/sj.bjc.6603843. Epub 2007 Jun 5.

Abstract

We followed a population-based cohort of 5696 women, 32-38 years of age, by registry linkage with cytology and pathology registries during a mean follow-up time of 4.1 years to assess the importance for CIN2+ development of type-specific HPV DNA positivity at baseline. HPV 16, 31 and 33 conveyed the highest risks and were responsible for 33.1, 18.3 and 7.7% of CIN2+ cases, respectively. Women infected with HPV 18, 35, 39, 45, 51, 52, 56, 58, 59 and 66 had significantly lower risks of CIN2+ than women infected with HPV 16. After adjustment for infection with other HPV types, HPV types 35, 45, 59 and 66 had no detectable association with CIN2+. In summary, the different HPV types found in cervical cancer show distinctly different CIN2+ risks, with high risks being restricted to HPV 16 and its close relatives HPV 31 and HPV 33.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Alphapapillomavirus / classification
  • Alphapapillomavirus / isolation & purification*
  • Cervical Intraepithelial Neoplasia / virology*
  • Cohort Studies
  • DNA, Viral / analysis
  • Female
  • Follow-Up Studies
  • Human papillomavirus 16 / isolation & purification
  • Humans
  • Incidence
  • Population Surveillance
  • Prospective Studies
  • Risk Factors

Substances

  • DNA, Viral