Abstract
An efficient method for the synthesis of enol ethers and enecarbamates has been developed based on catalytic hydrosilane reduction of alpha-phosphonoxy enol ethers and alpha-phosphonoxy enecarbamates. This method has been applied to the total syntheses of two isoindolobenzazepine alkaloids, lennoxamine and chilenine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemical synthesis*
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Alkaloids / chemistry
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Alkenes / chemical synthesis*
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Alkenes / chemistry
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Benzazepines / chemical synthesis*
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Benzazepines / chemistry
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Carbamates / chemical synthesis*
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Carbamates / chemistry
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Cyclization
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Dioxanes / chemical synthesis*
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Dioxanes / chemistry
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Ethers, Cyclic / chemical synthesis*
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Ethers, Cyclic / chemistry
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / chemistry
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Indoles / chemical synthesis*
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Indoles / chemistry
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Molecular Structure
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Oxidation-Reduction
Substances
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Alkaloids
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Alkenes
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Benzazepines
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Carbamates
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Dioxanes
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Ethers, Cyclic
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Heterocyclic Compounds
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Indoles
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chilenine
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lennoxamine