[Effects of 2-n-nonyl-1,3-dioxolane as an enhanceron transdermal absorption of Salvia miltiorrhiza gel]

Zhongguo Zhong Yao Za Zhi. 2007 Mar;32(6):487-9.
[Article in Chinese]

Abstract

Objective: To choose the most suitable concentration of 2-n-nonyl-1,3-dioxolane as a penetration enhancer in tanshinone gel preparation.

Method: In vitro, transdermal absorption was studied using improved Frans equipment and rats skin. Tanshinone II A was tested by HPLC.

Result: The 4.0% concentration of 2-n-nonyl-1,3-dioxolane enhanced the transdermal absorption significantly in the preparation.

Conclusion: 2-n-nonyl-1,3-dioxolane was a new effective permeaton enhancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abietanes
  • Administration, Cutaneous
  • Animals
  • Dioxolanes / administration & dosage
  • Dioxolanes / pharmacology*
  • Dose-Response Relationship, Drug
  • Drugs, Chinese Herbal / administration & dosage
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacokinetics*
  • Female
  • Gels
  • In Vitro Techniques
  • Male
  • Mice
  • Phenanthrenes / analysis
  • Reproducibility of Results
  • Salvia miltiorrhiza / chemistry*
  • Skin / drug effects
  • Skin / metabolism
  • Skin Absorption / drug effects*

Substances

  • Abietanes
  • Dioxolanes
  • Drugs, Chinese Herbal
  • Gels
  • Phenanthrenes
  • tanshinone
  • 2-n-nonyl-1,3-dioxolane