Abstract
Objective:
To choose the most suitable concentration of 2-n-nonyl-1,3-dioxolane as a penetration enhancer in tanshinone gel preparation.
Method:
In vitro, transdermal absorption was studied using improved Frans equipment and rats skin. Tanshinone II A was tested by HPLC.
Result:
The 4.0% concentration of 2-n-nonyl-1,3-dioxolane enhanced the transdermal absorption significantly in the preparation.
Conclusion:
2-n-nonyl-1,3-dioxolane was a new effective permeaton enhancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abietanes
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Administration, Cutaneous
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Animals
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Dioxolanes / administration & dosage
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Dioxolanes / pharmacology*
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Dose-Response Relationship, Drug
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Drugs, Chinese Herbal / administration & dosage
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacokinetics*
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Female
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Gels
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In Vitro Techniques
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Male
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Mice
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Phenanthrenes / analysis
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Reproducibility of Results
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Salvia miltiorrhiza / chemistry*
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Skin / drug effects
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Skin / metabolism
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Skin Absorption / drug effects*
Substances
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Abietanes
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Dioxolanes
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Drugs, Chinese Herbal
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Gels
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Phenanthrenes
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tanshinone
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2-n-nonyl-1,3-dioxolane