Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

J Proteome Res. 2007 Jul;6(7):2833-40. doi: 10.1021/pr0700753. Epub 2007 Jun 7.


Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomarkers / blood
  • Blood Proteins / analysis*
  • Blotting, Western
  • Central Nervous System / metabolism*
  • Electrophoresis, Gel, Two-Dimensional
  • Encephalitis / blood*
  • Encephalitis / immunology
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Huntington Disease / blood*
  • Huntington Disease / immunology
  • Interleukin-6 / blood
  • Mice
  • Protein Array Analysis
  • Proteomics*


  • Biomarkers
  • Blood Proteins
  • Interleukin-6