Imaging pancreatic cancer using surface-functionalized quantum dots

J Phys Chem B. 2007 Jun 28;111(25):6969-72. doi: 10.1021/jp070620n. Epub 2007 Jun 7.


In this study, CdSe/CdS/ZnS quantum dots (QDs) were used as optical contrast agent for imaging pancreatic cancer cells in vitro using transferrin and anti-Claudin-4 as targeting ligands. CdSe/CdS/ZnS was chosen because the CdSe/CdS/ZnS QDs have better photoluminescence (PL) efficiency and stability than those of CdSe/ZnS. The transferrin-mediated targeting is demonstrated in both a cell-free coprecipitation assay as well as using in vitro confocal microscopy. Pancreatic cancer specific uptake is also demonstrated using the monoclonal antibody anti-Claudin-4. This targeted QD platform will be further modified for the purpose of developing as an early detection imaging tool for pancreatic cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Contrast Media*
  • Humans
  • Microscopy, Electron, Transmission
  • Pancreatic Neoplasms / diagnosis*
  • Pancreatic Neoplasms / pathology*
  • Quantum Dots*


  • Contrast Media