Plasma/serum proteomics: pre-analytical issues

Expert Rev Proteomics. 2007 Jun;4(3):363-70. doi: 10.1586/14789450.4.3.363.


High-throughput proteomics technologies tend to provide highly sensitive information about living tissues and biological fluids. Analytes are characterized by intrinsic and extrinsic properties, the latter depending on each phase of their preparation, sometimes adding artifacts with crucial repercussions in result reliability and interpretation. This review aims to address some issues that can be encountered when handling plasma and serum in experimental and clinical proteomic settings.

Publication types

  • Review

MeSH terms

  • Blood Protein Electrophoresis / methods
  • Blood Proteins / analysis*
  • Electrophoresis, Gel, Two-Dimensional / methods
  • Plasma / metabolism*
  • Proteomics / methods*
  • Reproducibility of Results
  • Serum / metabolism*


  • Blood Proteins