Antimicrobial drugs and community-acquired Clostridium difficile-associated disease, UK

Emerg Infect Dis. 2007 May;13(5):761-3. doi: 10.3201/eid1305.061124.


In a population-based case-control study of community acquired Clostridium difficile-associated disease (CDAD), we matched 1,233 cases to 12,330 controls. CDAD risk increased 3-fold with use of any antimicrobial agent and 6-fold with use of fluoroquinolones. Prior use of antimicrobial agents did not affect risk for CDAD after 6 months.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / pharmacology
  • Case-Control Studies
  • Clostridium Infections / drug therapy*
  • Clostridium Infections / epidemiology
  • Clostridium difficile / drug effects*
  • Community-Acquired Infections / epidemiology
  • Community-Acquired Infections / microbiology
  • Databases, Factual
  • Drug Resistance, Multiple, Bacterial / drug effects*
  • Humans
  • United Kingdom / epidemiology


  • Anti-Bacterial Agents