Abstract
BACE initiates the production of beta-amyloid (Abeta), the likely cause of Alzheimer's disease (AD). In this issue of Neuron, Tesco et al. show that during apoptosis caspase-3 cleaves the adaptor protein GGA3, which is required for BACE lysosomal degradation, consequently stabilizing BACE and elevating Abeta generation.
MeSH terms
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ADP-Ribosylation Factors / metabolism*
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Adaptor Proteins, Vesicular Transport / metabolism*
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Alzheimer Disease / enzymology*
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Alzheimer Disease / physiopathology
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Amyloid Precursor Protein Secretases / metabolism*
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Amyloid beta-Peptides / biosynthesis
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Amyloid beta-Protein Precursor / metabolism*
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Animals
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Apoptosis / physiology
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Aspartic Acid Endopeptidases / metabolism*
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Caspase 3 / metabolism*
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Humans
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Protein Processing, Post-Translational / physiology
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Protein Transport / physiology
Substances
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Adaptor Proteins, Vesicular Transport
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Amyloid beta-Peptides
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Amyloid beta-Protein Precursor
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GGA adaptor proteins
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Amyloid Precursor Protein Secretases
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Caspase 3
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Aspartic Acid Endopeptidases
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BACE1 protein, human
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ADP-Ribosylation Factors