Flucloxacillin treatment of Staphylococcus aureus meningitis

Eur J Clin Microbiol Infect Dis. 2007 Jul;26(7):501-4. doi: 10.1007/s10096-007-0324-2.


In this paper, we aimed to evaluate the efficacy of flucloxacillin treatment of meningitis caused by methicillin-sensitive Staphylococcus aureus. We identified 33 patients with meningitis due to S. aureus; eight had community-acquired meningitis and 25 had neurosurgical meningitis. Six of the eight patients with community-acquired meningitis were cured. Eighteen of the 22 patients treated with flucloxacillin were cured without relapse (86%, 95%CI 65-97%) and their cerebrospinal fluid (CSF) cultures were sterile after a median of 3 days of treatment. The cure rate for 12 patients who also received an additional antibiotic at the outset of treatment was 75% (95%CI 43-95%). This was not different to the cure rate for the ten patients who received flucloxacillin alone 90% (95%CI 56-100%). We conclude that flucloxacillin is an effective treatment for meningitis caused by S. aureus.

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / therapeutic use*
  • Community-Acquired Infections / drug therapy
  • Cross Infection / drug therapy*
  • Cross Infection / microbiology
  • Female
  • Floxacillin / therapeutic use*
  • Humans
  • Male
  • Meningitis, Bacterial / cerebrospinal fluid
  • Meningitis, Bacterial / drug therapy*
  • Meningitis, Bacterial / microbiology
  • Middle Aged
  • Neurosurgical Procedures / adverse effects
  • Retrospective Studies
  • Staphylococcal Infections / drug therapy*


  • Anti-Bacterial Agents
  • Floxacillin