Prospects for a dengue virus vaccine

Nat Rev Microbiol. 2007 Jul;5(7):518-28. doi: 10.1038/nrmicro1690.


The number of cases of severe dengue disease continues to grow in endemic areas of southeast Asia, Central and South America, and other subtropical regions. Children bear the greatest burden of disease, and the development of an effective vaccine remains a global public health priority. A tetravalent vaccine is urgently needed and must be effective against all four dengue virus serotypes, be cost-effective and provide long-term protection. In this Review we discuss the unique immunological concerns in dengue virus vaccine development and the current prospects for the development of an acceptable vaccine, a goal that is likely to be reached in the near future.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Antibody-Dependent Enhancement
  • Asia, Southeastern / epidemiology
  • Central America / epidemiology
  • Child
  • Child, Preschool
  • Dengue / epidemiology
  • Dengue / immunology*
  • Dengue / prevention & control*
  • Dengue / virology
  • Dengue Vaccines / immunology*
  • Dengue Virus / classification
  • Dengue Virus / genetics
  • Dengue Virus / immunology*
  • Humans
  • South America / epidemiology
  • Vaccines, Attenuated / immunology
  • Vaccines, Synthetic / immunology


  • Dengue Vaccines
  • Vaccines, Attenuated
  • Vaccines, Synthetic