The inner gel component of Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells

Methods. 2007 Aug;42(4):388-93. doi: 10.1016/j.ymeth.2007.03.005.


The present study was carried out to examine the anti-inflammatory activity of the inner leaf gel component of Aloe barbadensis Miller. A simple in vitro assay was designed to determine the effect of the inner gel on bacterial-induced pro-inflammatory cytokine production, namely TNF-alpha and IL-1 beta, from peripheral blood leukocytes stimulated with Shigella flexneri or LPS. This report describes the suppression of both cytokines with a freeze-dried inner gel powder and a commercial health drink from the same source. Comparison was made with a human monocytic cell-line (THP-1 cells) and a similar trend in responses was demonstrated.

MeSH terms

  • Aloe / chemistry*
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Bacterial Outer Membrane Proteins / metabolism
  • Bacterial Outer Membrane Proteins / pharmacology
  • Cell Line
  • Cells, Cultured
  • Down-Regulation
  • Gels / chemistry
  • Gels / pharmacology*
  • Humans
  • Immune System / cytology*
  • Immune System / drug effects*
  • Inflammation / drug therapy
  • Interleukin-1 / biosynthesis
  • Plant Leaves / chemistry*
  • Tumor Necrosis Factor-alpha / biosynthesis


  • Anti-Inflammatory Agents
  • Bacterial Outer Membrane Proteins
  • Gels
  • Interleukin-1
  • Tumor Necrosis Factor-alpha