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. 2007 Jun;11(6):473-5.
doi: 10.1016/j.ccr.2007.05.003.

A CERTain Role for Ceramide in Taxane-Induced Cell Death

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A CERTain Role for Ceramide in Taxane-Induced Cell Death

Richard Kolesnick et al. Cancer Cell. .
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An unexpected benefit of functional genomic screens is that at times they answer questions that they were not designed to ask. A siRNA screen reported by Swanton et al. in this issue of Cancer Cell reveals that silencing of spindle assembly checkpoint genes facilitates mitotic slippage, resulting in escape from taxane-induced cell death, aneuploidy, and chromosomal instability, hallmarks of taxane resistance. Unexpectedly, the screen disclosed that the sphingolipid ceramide is a key regulator of the taxane-mediated spindle assembly checkpoint and taxane-induced cell death. Ceramide metabolism thus serves as a legitimate target for modulation of taxane effect on tumors.

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