Glucosamine/chondroitin combined with exercise for the treatment of knee osteoarthritis: a preliminary study

Osteoarthritis Cartilage. 2007 Nov;15(11):1256-66. doi: 10.1016/j.joca.2007.04.016. Epub 2007 Jun 11.


Objective: This preliminary study sought to determine whether using 1500/1200mg of glucosamine hydrochloride and chondroitin sulfate (GH/CS) is effective, both separately and combined with exercise, compared to a placebo plus exercise program in improving physical function, pain, strength, balance, and mobility in older adults with knee osteoarthritis (OA).

Methods: This double-blind, placebo-controlled, randomized clinical trial lasted 12 months. Participants included 89 older adults (age>/=50 years) with knee OA randomized to either GH/CS or placebo group. Phase I was a 6-month trial comparing the effects of assignment to either GH/CS or placebo. Phase II added 6 months of exercise for both groups. The primary outcome measure was Western Ontario and McMaster University Osteoarthritis Index (WOMAC) function, and secondary outcome measures included WOMAC pain, 6-min walk, balance, and knee strength.

Results: Of the 89 randomized participants, 72 (81%) completed the study. The median pill compliance was 94% and 95% in Phase I, and, in Phase II, 97% and 91% for the GH/CS and placebo groups, respectively. Median exercise compliance during Phase II was 77% for the GH/CS group and 78% for the placebo group. WOMAC function and pain did not differ significantly between the groups at 6- or 12-month follow-up. There were also no significant differences between the groups in 6-min walk or knee strength; however, balance was better in the placebo group with approximately a 10% difference compared to the GH/CS group.

Conclusions: The GH/CS group was not superior to the placebo group in function, pain, or mobility after both phases of the intervention (pill only and pill plus exercise).

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Analgesics, Non-Narcotic / therapeutic use*
  • Analysis of Variance
  • Chondroitin / therapeutic use*
  • Double-Blind Method
  • Exercise Therapy*
  • Female
  • Glucosamine / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Osteoarthritis, Knee / therapy*
  • Pain / diagnosis
  • Patient Compliance
  • Severity of Illness Index


  • Analgesics, Non-Narcotic
  • Chondroitin
  • Glucosamine