Glutathione S-transferases GSTM1 and GSTT1 polymorphisms and asbestosis

J Occup Environ Med. 2007 Jun;49(6):667-71. doi: 10.1097/JOM.0b013e318065b855.


Objective: In a nested case-control study, the authors investigated whether the deletion polymorphism of glutathione S-transferases GSTM1 and GSTT1 represents a risk factor for the development of asbestosis.

Methods: In total, 262 cases with asbestosis and 265 controls, selected from a cohort of 2080 workers occupationally exposed to asbestos, were genotyped for GSTM1 and GSTT1-null alleles. Cumulative exposure for each subject was available.

Results: Asbestosis was associated with cumulative exposure (odds ratio [OR]=3.21, confidence interval [CI] 2.43-4.23) and GSTT1-null genotype (OR=0.61, CI 0.40-0.94), but not with GSTM1-null genotype (OR=1.01, CI 0.71-1.43). The risk of GSTM1-null and GSTT1-null genotype for asbestosis did not change after adjustment by cumulative exposure, smoking, gender, and age.

Conclusions: An important finding of this study is that GSTT1 gene deletion might have a protective effect on the development of asbestosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Asbestosis / etiology
  • Asbestosis / genetics*
  • Case-Control Studies
  • Confidence Intervals
  • Female
  • Glutathione Transferase / genetics*
  • Humans
  • Male
  • Middle Aged
  • Occupational Exposure / adverse effects*
  • Polymorphism, Genetic*
  • Risk Factors


  • Glutathione Transferase