Planar cell polarity: one or two pathways?

Nat Rev Genet. 2007 Jul;8(7):555-63. doi: 10.1038/nrg2125. Epub 2007 Jun 12.


In multicellular organisms, cells are polarized in the plane of the epithelial sheet, revealed in some cell types by oriented hairs or cilia. Many of the underlying genes have been identified in Drosophila melanogaster and are conserved in vertebrates. Here we dissect the logic of planar cell polarity (PCP). We review studies of genetic mosaics in adult flies - marked cells of different genotypes help us to understand how polarizing information is generated and how it passes from one cell to another. We argue that the prevailing opinion that planar polarity depends on a single genetic pathway is wrong and conclude that there are (at least) two independently acting processes. This conclusion has major consequences for the PCP field.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Polarity / genetics*
  • Cilia / genetics
  • Clone Cells
  • Drosophila melanogaster / genetics*
  • Mice
  • Models, Biological
  • Morphogenesis
  • Signal Transduction*