Bridging the blood-brain barrier: new methods improve the odds of getting drugs to the brain cells that need them

PLoS Biol. 2007 Jun;5(6):e169. doi: 10.1371/journal.pbio.0050169.

Abstract

Researchers developing drugs to treat brain disorders face a major hurdle: crossing the blood-brain barrier. What will it take to translate billions of dollars of research into therapeutic success?

MeSH terms

  • Blood-Brain Barrier / metabolism*
  • Brain Diseases / drug therapy*
  • Carrier Proteins / metabolism
  • Drug Delivery Systems / methods*
  • Drug Therapy / methods*
  • Endothelial Cells / metabolism
  • Humans

Substances

  • Carrier Proteins