PrDOS: prediction of disordered protein regions from amino acid sequence

Nucleic Acids Res. 2007 Jul;35(Web Server issue):W460-4. doi: 10.1093/nar/gkm363. Epub 2007 Jun 12.


PrDOS is a server that predicts the disordered regions of a protein from its amino acid sequence ( The server accepts a single protein amino acid sequence, in either plain text or FASTA format. The prediction system is composed of two predictors: a predictor based on local amino acid sequence information and one based on template proteins. The server combines the results of the two predictors and returns a two-state prediction (order/disorder) and a disorder probability for each residue. The prediction results are sent by e-mail, and the server also provides a web-interface to check the results.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Amino Acid Sequence
  • Artificial Intelligence*
  • Computational Biology / methods*
  • Computing Methodologies
  • Databases, Protein
  • Gene Products, nef / chemistry
  • Models, Statistical
  • Molecular Sequence Data
  • Pattern Recognition, Automated / methods*
  • Protein Conformation
  • Proteins / analysis*
  • Proteins / chemistry*
  • Sequence Alignment / methods*
  • Sequence Analysis, Protein / methods*
  • nef Gene Products, Human Immunodeficiency Virus


  • Gene Products, nef
  • Proteins
  • nef Gene Products, Human Immunodeficiency Virus