Finding Plk3

Cell Cycle. 2007 Jun 1;6(11):1314-8. doi: 10.4161/cc.6.11.4275. Epub 2007 Jun 11.

Abstract

Polo-like kinases (Plks) are a highly conserved family of kinases found in flies, yeast and vertebrates. Plks derive their name from homology to the gene product of polo, a protein kinase first identified in Drosophila. Three polo-like kinases have been identified in vertebrates: Plk1, Plk2 and Plk3. Studies on Plk1 have revealed a great deal of information on its multiple functions, however Plk2 and Plk3 functions have not been fully explored. In this perspective we discuss recent work on Plk3 expression, function and localization in the context of previous reports on Plk3 and in terms of its relationship to Plk1.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / physiology
  • Cell Line
  • Cell Nucleolus / enzymology*
  • Cyclin E / metabolism
  • Enzyme Induction
  • G1 Phase / physiology
  • Genes, Immediate-Early
  • Humans
  • Mammals / metabolism
  • Mice
  • Mice, Knockout
  • Protein Structure, Tertiary
  • Protein-Serine-Threonine Kinases / deficiency
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / isolation & purification
  • Protein-Serine-Threonine Kinases / physiology*
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / physiology
  • S Phase / physiology
  • Substrate Specificity
  • Vertebrates / metabolism*

Substances

  • Cell Cycle Proteins
  • Cyclin E
  • Proto-Oncogene Proteins
  • PLK3 protein, human
  • Plk3 protein, mouse
  • Protein-Serine-Threonine Kinases
  • polo-like kinase 1