Efficacy of Monascus purpureus Went rice on lowering lipid ratios in hypercholesterolemic patients

Eur J Cardiovasc Prev Rehabil. 2007 Jun;14(3):438-40. doi: 10.1097/HJR.0b013e32801da137.


Background: Several lipid ratios may be predictors of coronary artery disease risk. We assessed the efficacy of Monascus purpureus Went rice (red yeast rice) on lowering lipid ratios.

Method and results: We evaluated 79 hypercholesterolemic patients (aged 23-65 years) who received a twice-daily dose of either red yeast rice or a placebo at 600 mg for 8 weeks. The 8-week treatment with red yeast rice showed significantly greater reduction than the placebo treatment in low-density lipoprotein cholesterol levels, total cholesterol/high-density lipoprotein cholesterol, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and apolipoprotein B/apolipoprotein A-I ratios.

Conclusions: Red yeast rice can reduce lipid ratios in hypercholesterolemic patients.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Anticholesteremic Agents / administration & dosage
  • Anticholesteremic Agents / therapeutic use*
  • Apolipoprotein A-I / blood
  • Apolipoproteins B / blood
  • Biological Products / administration & dosage
  • Biological Products / therapeutic use*
  • Capsules
  • Cholesterol / blood
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Humans
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / drug therapy*
  • Lipids / blood*
  • Male
  • Middle Aged
  • Monascus*
  • Phytotherapy*
  • Treatment Outcome


  • Anticholesteremic Agents
  • Apolipoprotein A-I
  • Apolipoproteins B
  • Biological Products
  • Capsules
  • Lipids
  • red yeast rice
  • Cholesterol