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. 2007 Sep;61(9):790-4.
doi: 10.1002/syn.20427.

Dietary Restriction Modulates Alpha-Synuclein Expression in the Aging Rat Cortex and Hippocampus

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Dietary Restriction Modulates Alpha-Synuclein Expression in the Aging Rat Cortex and Hippocampus

Aleksandra Mladenovic et al. Synapse. .

Abstract

Dietary restriction (DR) is one of the promising environmental interventions known to attenuate aging and decrease risk of age-related neurodegenerative disorders. The aim of this study was to assess the effects of DR on expression of alpha-synuclein, a presynaptic protein involved in pathogenesis of Parkinson's and some other neurodegenerative diseases, in the cortex and hippocampus of adult, middle-aged, late middle-aged, and aged rats. Using Real Time RT-PCR, the authors report that aging regulates the expression of alpha-synuclein in a tissue-specific manner and that long-term DR reverts the late age-related changes of alpha-synuclein expression.

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