The regulation of permeability barrier homeostasis

J Invest Dermatol. 2007 Jul;127(7):1574-6. doi: 10.1038/sj.jid.5700774.

Abstract

Disruption of the permeability barrier stimulates a repair response that leads to the restoration of barrier function. Previous studies demonstrated that changes in ions, particularly calcium, and cytokines are positive signals, whereas serine protease activation of proteinase-activated receptor 2 is a negative signal regulating barrier recovery. Ikeyama and colleagues provide data that the nitric oxide signaling pathway also regulates barrier homeostasis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Calcium / physiology
  • Cell Membrane Permeability / physiology*
  • Cytokines / physiology
  • Homeostasis / physiology*
  • Humans
  • Mice
  • Mice, Knockout
  • Nitric Oxide / physiology*
  • Nitric Oxide Synthase Type I / genetics
  • Nitric Oxide Synthase Type I / physiology
  • Receptor, PAR-2 / genetics
  • Receptor, PAR-2 / physiology
  • Serine Endopeptidases / physiology
  • Signal Transduction / physiology
  • Skin / cytology
  • Skin Physiological Phenomena*

Substances

  • Cytokines
  • Receptor, PAR-2
  • Nitric Oxide
  • Nitric Oxide Synthase Type I
  • Serine Endopeptidases
  • Calcium